Purpose of review: Despite the emergence of molecular targeted systemic therapy for metastatic renal cell carcinoma, cure is uncommonly achieved in the absence of surgical resection. We review the current role of metastasectomy and factors associated with outcome.
Recent findings: Recent publication of large observational studies has better defined the expected prognosis of patients with metastatic renal cell carcinoma with or without metastasectomy. These data have highlighted prognostic factors for survival in patients treated with metastasectomy.
Summary: Patients with metastatic renal cell carcinoma should be considered for multimodal therapy, including surgery. A proportion of patients will achieve long-term survival with aggressive surgical resection.