Abstract
A series of triarylolefins bearing the combretastatin A-4 and the isocombretastatin A-4 cores were synthesized and evaluated. The cooperative ortho-effect of a labile bromine atom in the regioselective hydrostannation of unsymmetrical diarylalkynes leading to stereodefined triarylolefins is presented.
2010 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemical synthesis
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Alkenes / chemistry*
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Alkenes / pharmacology
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Alkynes / chemistry*
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Bromine / chemistry*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Chlorophenols / chemistry*
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Humans
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Organotin Compounds / chemistry*
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Peptides, Cyclic / chemistry*
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Stereoisomerism
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Stilbenes / chemistry*
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Substrate Specificity
Substances
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Alkenes
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Alkynes
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Antineoplastic Agents
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Chlorophenols
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Organotin Compounds
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Peptides, Cyclic
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Stilbenes
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hydrostannane
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complestatin
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fosbretabulin
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Bromine