Comment on M.V. Evans and J.C. Caldwell: evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic modeling of in vivo gas uptake data exposure in female B6C3F1 mice, Toxicol. Appl. Pharmacol., 244, 280-290, 2010

Toxicol Appl Pharmacol. 2010 Oct 1;248(1):63-4; author reply 65-7. doi: 10.1016/j.taap.2010.07.012. Epub 2010 Jul 22.

Authors

M W Anders, Melvin E Andersen, Harvey J Clewell 3rd, Michael L Gargas, F Peter Guengerich, Richard H Reitz

PMID: 20655322
DOI: 10.1016/j.taap.2010.07.012

No abstract available

Publication types

Comment
Letter

MeSH terms

Animals
Cytochrome P-450 CYP2E1 / metabolism*
Female
Glutathione Transferase / metabolism
Methylene Chloride / pharmacokinetics
Methylene Chloride / toxicity*
Mice
Models, Biological*
Risk Assessment / methods

Substances

Methylene Chloride
Cytochrome P-450 CYP2E1
Glutathione Transferase