Synthesis of gamma-halogenated ketones via the Ce(IV)-mediated oxidative coupling of cyclobutanols and inorganic halides

Brian M Casey; Cynthia A Eakin; Robert A Flowers

doi:10.1016/j.tetlet.2008.12.114

Synthesis of gamma-halogenated ketones via the Ce(IV)-mediated oxidative coupling of cyclobutanols and inorganic halides

Tetrahedron Lett. 2009 Mar 25;50(12):1264-1266. doi: 10.1016/j.tetlet.2008.12.114.

Authors

Brian M Casey¹, Cynthia A Eakin, Robert A Flowers

Affiliation

¹ Department of Chemistry, Lehigh University, Bethlehem, PA 18015, USA.

Abstract

A straightforward method for the synthesis of gamma-halo-substituted ketones formed via the CAN-initiated oxidative addition of halides to 1-substituted cyclobutanols has been developed. This method has short reaction times, and provides access to a range of bromo and iodo gamma-substituted ketones in good to excellent yields.

Abstract

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