Differential DNA damage response in stem and progenitor cells

Jun Seita; Derrick J Rossi; Irving L Weissman

doi:10.1016/j.stem.2010.07.006

Differential DNA damage response in stem and progenitor cells

Cell Stem Cell. 2010 Aug 6;7(2):145-7. doi: 10.1016/j.stem.2010.07.006.

Authors

Jun Seita¹, Derrick J Rossi, Irving L Weissman

Affiliation

¹ Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. jseita@stanford.edu

PMID: 20682442
DOI: 10.1016/j.stem.2010.07.006

Abstract

The long lifespan of tissue-specific stem cells suggests that they may respond differently to DNA damage than downstream cells. In this issue of Cell Stem Cell, two groups address this hypothesis by examining DNA damage responses in hematopoietic stem and progenitor cells (Milyavsky et al., 2010; Mohrin et al., 2010).

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