Abstract
We recently found that lithocholic acid (LCA), a bile acid, extends yeast longevity. Unlike mammals, yeast do not synthesize bile acids. We therefore propose that bile acids released into the environment by mammals may act as interspecies chemical signals providing longevity benefits to yeast and, perhaps, other species within an ecosystem.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Caloric Restriction
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Cyclic AMP-Dependent Protein Kinases / metabolism
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Cytostatic Agents / metabolism
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Ecosystem*
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Lithocholic Acid*
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Longevity* / physiology
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Mammals* / physiology
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Mitochondria / physiology
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Signal Transduction / physiology
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Sirolimus / metabolism
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TOR Serine-Threonine Kinases / metabolism
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Xenobiotics / metabolism
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Yeasts / physiology
Substances
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Cytostatic Agents
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Xenobiotics
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Lithocholic Acid
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TOR Serine-Threonine Kinases
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Cyclic AMP-Dependent Protein Kinases
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Sirolimus