Discounting of delayed rewards and executive dysfunction in individuals infected with hepatitis C

J Clin Exp Neuropsychol. 2011 Feb;33(2):176-86. doi: 10.1080/13803395.2010.499355. Epub 2010 Aug 6.

Abstract

Objective: Determine whether adults with hepatitis C (HCV), regardless of substance use disorder, are more likely to discount delayed rewards than adults without hepatitis C, and explore the relationship between delay discounting and neuropsychological functioning.

Methods: Procedures included clinical interviews, neuropsychological testing, and a delay discounting task.

Results: Regardless of substance abuse history, adults with hepatitis C were significantly more likely to choose smaller immediate rewards over larger delayed rewards. Delay discounting correlated with performance on executive functioning tasks.

Conclusions: Increased discounting is associated with broad executive dysfunction, suggesting that HCV-associated executive dysfunction may lead to altered decision-making style.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Analysis of Variance
  • Choice Behavior
  • Cognition / physiology
  • Data Interpretation, Statistical
  • Decision Making / physiology
  • Depression / psychology
  • Executive Function / physiology*
  • Female
  • Hepatitis C, Chronic / complications
  • Hepatitis C, Chronic / psychology*
  • Humans
  • Impulsive Behavior / etiology
  • Impulsive Behavior / psychology*
  • Male
  • Memory / physiology
  • Mental Disorders / complications
  • Mental Disorders / psychology
  • Middle Aged
  • Neuropsychological Tests
  • Psychomotor Performance / physiology
  • Reward*
  • Substance-Related Disorders / complications
  • Substance-Related Disorders / psychology
  • Veterans