Abstract
Use of rodent models of hippocampal neurodegeneration are recommended for use in studies to understand the pathophysiology and molecular mechanisms involved. This unit includes protocols for two-vessel occlusion, three-vessel occlusion, and permanent bilateral vertebral artery occlusion plus methods for histological techniques for preparation of brain tissue and analysis of hippocampal injury.
MeSH terms
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Animals
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Arterial Occlusive Diseases* / complications
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Basilar Artery / pathology
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Basilar Artery / physiopathology
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Brain Ischemia* / etiology
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Brain Ischemia* / pathology
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Brain Ischemia* / physiopathology
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Carotid Artery, Common / pathology
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Carotid Artery, Common / physiopathology
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Disease Models, Animal*
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Hippocampus / blood supply
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Hippocampus / physiopathology
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Mice
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Nerve Degeneration / pathology*
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Vertebral Artery / pathology
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Vertebral Artery / physiopathology