Abstract
Spirooxindole amides can be prepared by the intramolecular addition of functionalized indoles into acylimines that are accessed from nitriles by hydrozirconation and acylation. The stereochemical outcome at the quaternary center was controlled by the steric bulk of the substituent at the 2-position of the indole unit. The products are well-suited for diversification to prepare libraries.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Acylation
-
Amides / chemical synthesis*
-
Amides / chemistry
-
Catalysis
-
Combinatorial Chemistry Techniques
-
Indoles / chemical synthesis*
-
Indoles / chemistry
-
Molecular Structure
-
Nitriles / chemistry*
-
Spiro Compounds / chemical synthesis*
-
Spiro Compounds / chemistry
-
Stereoisomerism
Substances
-
Amides
-
Indoles
-
Nitriles
-
Spiro Compounds