Plasma efavirenz in HIV infected children treated with generic antiretroviral drugs in India

Indian Pediatr. 2010 Oct;47(10):890-1.

Abstract

We measured plasma concentration of efavirenz (EFV) in 16 HIV-infected Indian children receiving antiretroviral treatment at Government ART centres. The mean 12 hour concentration was 2.39 ug/mL (range: 0.72- 7.82 ug/mL). The majority of children treated with generic EFV at currently recommended doses had blood levels within the therapeutic range.

Publication types

  • Letter
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alkynes
  • Anti-HIV Agents / pharmacokinetics*
  • Anti-HIV Agents / therapeutic use
  • Benzoxazines / pharmacokinetics*
  • Benzoxazines / therapeutic use
  • Child
  • Cyclopropanes
  • Drugs, Generic / pharmacokinetics*
  • Drugs, Generic / therapeutic use
  • Female
  • HIV Infections / drug therapy*
  • HIV Infections / metabolism
  • Humans
  • India
  • Male
  • Reverse Transcriptase Inhibitors / pharmacokinetics*
  • Reverse Transcriptase Inhibitors / therapeutic use

Substances

  • Alkynes
  • Anti-HIV Agents
  • Benzoxazines
  • Cyclopropanes
  • Drugs, Generic
  • Reverse Transcriptase Inhibitors
  • efavirenz