Multiple desmoplastic melanomas in Birt-Hogg-Dubé syndrome and a proposed signaling link between folliculin, the mTOR pathway, and melanoma susceptibility

Arch Dermatol. 2010 Nov;146(11):1316-8. doi: 10.1001/archdermatol.2010.333.

Authors

Raymond A Cocciolone, Kerry A Crotty, Lesley Andrews, Nikolas K Haass, Fergal J Moloney

PMID: 21079084
DOI: 10.1001/archdermatol.2010.333

No abstract available

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Birt-Hogg-Dube Syndrome / complications
Birt-Hogg-Dube Syndrome / genetics
Birt-Hogg-Dube Syndrome / metabolism
Birt-Hogg-Dube Syndrome / pathology*
Humans
Male
Melanoma / complications
Melanoma / pathology*
Melanoma / surgery
Middle Aged
Mutation
Neoplasm Recurrence, Local
Proto-Oncogene Proteins / genetics*
Proto-Oncogene Proteins / metabolism
Signal Transduction
Skin Neoplasms / complications
Skin Neoplasms / pathology*
Skin Neoplasms / surgery
TOR Serine-Threonine Kinases / metabolism*
Tumor Suppressor Proteins / genetics*
Tumor Suppressor Proteins / metabolism

Substances

FLCN protein, human
Proto-Oncogene Proteins
Tumor Suppressor Proteins
TOR Serine-Threonine Kinases