Serum unconjugated bisphenol A concentrations in women may adversely influence oocyte quality during in vitro fertilization

Fertil Steril. 2011 Apr;95(5):1816-9. doi: 10.1016/j.fertnstert.2010.11.008. Epub 2010 Dec 4.

Abstract

Bisphenol A (BPA) is an endocrine disruptor with estrogenic properties that can adversely affect meiotic spindle assemblies. Our data indicate that BPA exposure in female patients may interfere with oocyte quality during IVF, as suggested by the inverse association between serum unconjugated BPA concentration and normal fertilization.

Publication types

  • Clinical Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Benzhydryl Compounds
  • Endocrine Disruptors / analysis
  • Endocrine Disruptors / blood
  • Endocrine Disruptors / toxicity
  • Female
  • Fertilization / drug effects
  • Fertilization / physiology
  • Fertilization in Vitro*
  • Humans
  • Infertility / etiology
  • Infertility / therapy
  • Male
  • Oocytes / cytology*
  • Oocytes / drug effects*
  • Osmolar Concentration
  • Ovulation Induction / methods
  • Phenols / analysis
  • Phenols / blood*
  • Phenols / toxicity*
  • Pregnancy
  • Quality Control

Substances

  • Benzhydryl Compounds
  • Endocrine Disruptors
  • Phenols
  • bisphenol A