More than one way to make a tail

William F Marzluff

doi:10.1038/emboj.2010.306

More than one way to make a tail

EMBO J. 2010 Dec 15;29(24):4066-7. doi: 10.1038/emboj.2010.306.

Author

William F Marzluff¹

Affiliation

¹ Program in Molecular Biology and Biotechnology, Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA. marzluff@med.unc.edu

Abstract

The 3′UTR in mRNAs plays an important role in regulating the expression of the corresponding transcripts. Here Bill Marzluff highlights work from the Anderson lab that describes an unexpected active role for a non-canonical poly(A) polymerase in regulating 3′ end cleavage and polyadenylation of specific stress responsive transcripts.

Publication types

Comment

MeSH terms

Polynucleotide Adenylyltransferase / metabolism*
RNA Precursors / metabolism*
RNA Processing, Post-Transcriptional*
Sensitivity and Specificity

Substances

RNA Precursors
Polynucleotide Adenylyltransferase