Abstract
New N-hydroxypyridones, militarinones E (1) and F (2), phenylhydrazones, farylhydrazones A (3) and B (4), a quinazolinone, 2-(4-hydroxybenzyl)quinazolin-4(3H)-one (5), and the known militarinones A (6) and B (7) were isolated from cultures of the Cordyceps-colonizing fungus Isaria farinosa. The structures of 1-5 were elucidated by spectroscopic methods, and 3 was confirmed by X-ray crystallography. The absolute configuration of the C-4' secondary alcohol in 1 was deduced via the circular dichroism data of the in situ formed [Rh(2)(OCOCF(3))(4)] complex. Compounds 1 and 6 showed significant cytotoxicity against A549 cells, whereas 7 was active against Staphylococcus aureus, Streptococcus pneumoniae, and Candida albicans.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Candida albicans / drug effects
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Cordyceps / chemistry*
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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Humans
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Hydrazones / chemistry
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Hydrazones / isolation & purification*
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Hydrazones / pharmacology
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Hypocreales / chemistry*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Pyridones / chemistry
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Pyridones / isolation & purification*
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Pyridones / pharmacology
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Quinazolinones / chemistry
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Quinazolinones / isolation & purification*
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Quinazolinones / pharmacology
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Staphylococcus aureus / drug effects
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Streptococcus pneumoniae / drug effects
Substances
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Antineoplastic Agents
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Hydrazones
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Pyridones
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Quinazolinones
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phenylhydrazone