Abstract
Mossy fiber to CA3 synapses exhibit metaplasticity during the development of epilepsy, and valproate in control animals can modulate long-term plasticity at this synapse. Here we show that valproate alters frequency facilitation (short-term plasticity) at this synapse in hippocampal slices from post-status epilepticus but not control animals. This indicates that valproate can have specific actions in the "epileptic" brain.
Copyright © 2010 Elsevier B.V. All rights reserved.
MeSH terms
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Animals
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Anticonvulsants / therapeutic use*
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CA3 Region, Hippocampal / physiopathology*
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Electric Stimulation
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Electrodes, Implanted
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Electrophysiological Phenomena
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Excitatory Postsynaptic Potentials / drug effects
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Excitatory Postsynaptic Potentials / physiology
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Male
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Microelectrodes
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Mossy Fibers, Hippocampal / physiology*
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Neuronal Plasticity / drug effects
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Neuronal Plasticity / physiology
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Rats
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Rats, Sprague-Dawley
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Status Epilepticus / drug therapy*
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Status Epilepticus / physiopathology*
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Synapses / physiology
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Valproic Acid / therapeutic use*
Substances
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Anticonvulsants
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Valproic Acid