A water-soluble calix[4]resorcinarene with α-methyl-L-prolinylmethyl groups as a chiral NMR solvating agent

Ngoc H Pham; Thomas J Wenzel

doi:10.1021/jo102197w

A water-soluble calix[4]resorcinarene with α-methyl-L-prolinylmethyl groups as a chiral NMR solvating agent

J Org Chem. 2011 Feb 4;76(3):986-9. doi: 10.1021/jo102197w. Epub 2011 Jan 4.

Authors

Ngoc H Pham¹, Thomas J Wenzel

Affiliation

¹ Department of Chemistry, Bates College, Lewiston, Maine 04240, USA.

PMID: 21204543
DOI: 10.1021/jo102197w

Abstract

A water-soluble calix[4]resorcinarene containing α-methyl-L-prolinylmethyl groups is synthesized and evaluated as a chiral NMR solvating agent. Aryl-containing substrates with substituted amines are studied.