Five cases of Osgood-Schlatter's disease are reported. Two of them were siblings. The history and physical examination data are reported. A remarkable type of presentation was pain and swelling over the anterior tibial epiphysis. Radiological findings were always characteristic. The need to rule out this condition is emphasized for the differential diagnosis of other types of musculoskeletal pain in teenagers, as it has particular prognostic and therapeutic implications. The primary care physician plays a prominent role in its detection and therapy.