Pleuropulmonary fibrosis due to bromocriptine treatment for Parkinson's disease

Clin Exp Neurol. 1990:27:79-82.

Abstract

Pleuroplumonary fibrosis is an uncommon but potentially serious adverse effect of bromocriptine used in the treatment of Parkinson's disease. Two cases of this reaction, which occurred 12 months and 5 months respectively after commencing therapy are here reported. In both instances prompt clinical and radiological improvement occurred when bromocriptine intake was ceased. Fibrotic reactions to bromocriptine may be mediated by a serotonergic mechanism. Periodic monitoring of pulmonary symptoms is warranted in patients receiving bromocriptine treatment for Parkinson's disease.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Benserazide / therapeutic use
  • Bromocriptine / adverse effects*
  • Bromocriptine / therapeutic use
  • Drug Therapy, Combination
  • Humans
  • Levodopa / therapeutic use
  • Male
  • Middle Aged
  • Parkinson Disease / complications
  • Parkinson Disease / drug therapy*
  • Pulmonary Fibrosis / chemically induced*
  • Serotonin / metabolism

Substances

  • Serotonin
  • Bromocriptine
  • Levodopa
  • Benserazide