Abstract
Two new oleanane triterpenoids (1-2) and one new vibsane-type diterpenoid (3), together with 7 known compounds (4-10), were isolated from the leaves of Viburnum chingii. The structures of compounds 1-3 were elucidated by means of spectroscopic methods including extensive 1D- and 2D-NMR technique. Cytotoxicity of compounds 1-10 were tested against HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 cell lines. Compound 3 showed significant cytotoxicity against HL-60, SK-BR-3, and PANC-1 cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / toxicity
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Cell Line, Tumor
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Diterpenes / toxicity
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Drug Screening Assays, Antitumor
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Oleanolic Acid / chemistry*
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Oleanolic Acid / isolation & purification
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Oleanolic Acid / pharmacology
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Oleanolic Acid / toxicity
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Plant Leaves / chemistry
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Triterpenes / chemistry*
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Triterpenes / isolation & purification
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Triterpenes / toxicity
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Viburnum / chemistry*
Substances
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1alpha,3beta-dihydroxy-11a -methoxy-olean-12-ene
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1alpha,3beta-dihydroxy-olean-9(11),12-dien
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2alpha,3beta -dihydroxy-20(29)-lupene
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Triterpenes
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Oleanolic Acid