Reconsidering recent myocardial infarction as a contraindication for IV stroke thrombolysis

Neurology. 2011 May 24;76(21):1838-40. doi: 10.1212/WNL.0b013e31821ccc72. Epub 2011 Apr 13.

Abstract

Objectives: We reviewed the literature on IV stroke thrombolysis for patients with recent myocardial infarction (MI).

Methods: We searched PubMed and Ovid databases, relevant trials, and guidelines.

Results: Only 5 thrombolyzed stroke patients with recent MI were reported to have cardiac tamponade. Pathological studies show MI healing is completed by 7 weeks.

Conclusion: The time window from MI as a contraindication for IV stroke thrombolysis may be narrowed from 3 months in current guidelines to 7 weeks.

MeSH terms

  • Clinical Trials as Topic
  • Contraindications
  • Fibrinolytic Agents / therapeutic use*
  • Guidelines as Topic
  • Humans
  • Myocardial Infarction / complications*
  • PubMed
  • Risk Factors
  • Stroke / drug therapy*
  • Thrombolytic Therapy*
  • Time Factors
  • Treatment Outcome

Substances

  • Fibrinolytic Agents