The emerging role of APC/CCdh1 in development

Semin Cell Dev Biol. 2011 Aug;22(6):579-85. doi: 10.1016/j.semcdb.2011.03.012. Epub 2011 Apr 7.

Abstract

The function of APC/C (anaphase-promoting complex/cyclosome) was initially implicated with the onset of anaphase during mitosis, where its association with Cdc20 targets securin for destruction, thereby allowing the separation of two duplicated daughter genomes. When combined with Cdh1, APC regulates G1/S transition and DNA replication during cell cycle. Beyond cell cycle control, results from recent biochemical and mouse genetic studies have attracted our attention to the unexpected impact of APC/C(Cdh1) in cellular differentiation, genomic integrity and pathogenesis of various diseases. This review will aim to summarize current understanding of APC/C(Cdh1) in regulating crucial events during development.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Anaphase / physiology*
  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Antigens, CD
  • Cadherins / genetics
  • Cadherins / metabolism*
  • Cdc20 Proteins
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • DNA Replication
  • G1 Phase / physiology*
  • Gene Expression Regulation, Developmental*
  • Genomic Instability
  • Hematopoiesis / physiology
  • Humans
  • Mice
  • Neurogenesis / physiology
  • Oogenesis / physiology
  • Protein Binding
  • Resting Phase, Cell Cycle / physiology*
  • Ubiquitin-Protein Ligase Complexes / genetics
  • Ubiquitin-Protein Ligase Complexes / metabolism*
  • Ubiquitin-Protein Ligases / genetics
  • Ubiquitin-Protein Ligases / metabolism*
  • Ubiquitination

Substances

  • Antigens, CD
  • CDH1 protein, human
  • Cadherins
  • Cdc20 Proteins
  • Cell Cycle Proteins
  • CDC20 protein, human
  • Ubiquitin-Protein Ligase Complexes
  • Anaphase-Promoting Complex-Cyclosome
  • Ubiquitin-Protein Ligases