Seizure control: a secondary benefit of chemotherapeutic temozolomide in brain cancer patients

Epilepsy Res. 2011 Aug;95(3):270-2. doi: 10.1016/j.eplepsyres.2011.03.018. Epub 2011 May 5.

Abstract

The severity of brain tumor associated seizures often mirror the growth of the underlying tumor, and may be intractable to conventional antiepileptic drugs. We present a patient with intractable seizures in the setting of a low grade glioma who responded dramatically to temozolomide despite minimal radiographic change in tumor size. Temozolomide is an effective treatment for seizure control in patients with brain tumors.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents, Alkylating / therapeutic use*
  • Astrocytoma / complications
  • Brain Neoplasms / complications
  • Brain Neoplasms / drug therapy*
  • Dacarbazine / analogs & derivatives*
  • Dacarbazine / therapeutic use
  • Electroencephalography
  • Female
  • Humans
  • Seizures / drug therapy*
  • Seizures / etiology
  • Temozolomide

Substances

  • Antineoplastic Agents, Alkylating
  • Dacarbazine
  • Temozolomide