Ni(II)/Zn catalyzed reductive coupling of aryl halides with diphenylphosphine oxide in water

Xinghua Zhang; Huizhi Liu; Xiaomei Hu; Guo Tang; Jun Zhu; Yufen Zhao

doi:10.1021/ol201141m

Ni(II)/Zn catalyzed reductive coupling of aryl halides with diphenylphosphine oxide in water

Org Lett. 2011 Jul 1;13(13):3478-81. doi: 10.1021/ol201141m. Epub 2011 May 27.

Authors

Xinghua Zhang¹, Huizhi Liu, Xiaomei Hu, Guo Tang, Jun Zhu, Yufen Zhao

Affiliation

¹ Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China.

PMID: 21619044
DOI: 10.1021/ol201141m

Abstract

P-Arylation in water has been developed via cross-coupling of aryl halides with diphenylphosphine oxide (Ph(2)P(O)H) and (R(P))-(-)-menthyl benzylphosphinate catalyzed by NiCl(2)·6H(2)O/Zn under relatively mild conditions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bromine / chemistry*
Catalysis
Iodides / chemistry*
Models, Molecular
Molecular Structure
Nickel / chemistry*
Oxidation-Reduction
Oxides / chemistry*
Phosphines / chemistry*
Water / chemistry
Zinc / chemistry*

Substances

Iodides
Oxides
Phosphines
Water
Nickel
phosphine
Zinc
Bromine