Abstract
EMBO J 30 11, 2153–2166 (2011); published online April 15 2011
Actin and actin-related proteins (Arps) are critical components of chromatin remodelling and modifying complexes, where they are commonly found in pairs. Yet, little is known about their role in these complexes. In this issue of The EMBO Journal, Fenn et al (2011) report the first structural investigation of two nuclear Arps, the INO80 complex subunits Arp4 and Arp8. Importantly, their results also shed light on the critical role that the nucleotide state of actin may have on its interactions with the Arps.
Publication types
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Research Support, N.I.H., Extramural
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Comment
MeSH terms
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Actins / chemistry
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Actins / metabolism*
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Cell Nucleus / physiology
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Chromatin Assembly and Disassembly
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Microfilament Proteins / chemistry*
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Microfilament Proteins / metabolism*
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Models, Biological
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Nuclear Proteins / chemistry*
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Nuclear Proteins / metabolism*
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Protein Binding
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Saccharomyces cerevisiae / physiology
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Saccharomyces cerevisiae Proteins / chemistry*
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Saccharomyces cerevisiae Proteins / metabolism*
Substances
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ARP8 protein, S cerevisiae
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Actins
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Arp4 protein, S cerevisiae
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Microfilament Proteins
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Nuclear Proteins
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Saccharomyces cerevisiae Proteins