Imaging brain tumor by dendrimer-based optical/paramagnetic nanoprobe across the blood-brain barrier

Chem Commun (Camb). 2011 Jul 28;47(28):8130-2. doi: 10.1039/c1cc12007g. Epub 2011 May 31.

Abstract

A multimodal optical/paramagnetic nanoprobe, Den-Angio, was developed and demonstrated a capability to circumvent the blood brain barrier (BBB) and visualize brain tumors with high sensitivity in vivo. Den-Angio holds promise to pre-operatively localize brain tumors and make image-guided tumor resection possible during surgery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood-Brain Barrier / metabolism*
  • Brain Neoplasms / metabolism*
  • Cell Line, Tumor
  • Dendrimers / chemistry*
  • Humans
  • Magnetics*
  • Mice
  • Molecular Imaging / methods*
  • Molecular Probes / chemistry
  • Molecular Probes / metabolism*
  • Optical Phenomena*

Substances

  • Dendrimers
  • Molecular Probes