Abstract
A multimodal optical/paramagnetic nanoprobe, Den-Angio, was developed and demonstrated a capability to circumvent the blood brain barrier (BBB) and visualize brain tumors with high sensitivity in vivo. Den-Angio holds promise to pre-operatively localize brain tumors and make image-guided tumor resection possible during surgery.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Blood-Brain Barrier / metabolism*
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Brain Neoplasms / metabolism*
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Cell Line, Tumor
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Dendrimers / chemistry*
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Humans
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Magnetics*
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Mice
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Molecular Imaging / methods*
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Molecular Probes / chemistry
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Molecular Probes / metabolism*
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Optical Phenomena*
Substances
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Dendrimers
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Molecular Probes