A plexiform fibrohistiocytic tumor was analyzed cytogenetically after short-term in vitro culture. The stemline karyotype of this tumor was interpreted as 46,XY, -6, -8,del(4)(q25q31), del(20)(q11.2), + der(8)t(8;?)(p22;?), + mar. We believe this to be the first report of chromosome findings in this recently described histological entity.