Gami-Chunghyuldan ameliorates memory impairment and neurodegeneration induced by intrahippocampal Aβ 1-42 oligomer injection

Neurobiol Learn Mem. 2011 Sep;96(2):306-14. doi: 10.1016/j.nlm.2011.06.004. Epub 2011 Jun 13.

Abstract

Soluble oligomeric forms of amyloid beta (AβO) are regarded as a main cause of synaptic and cognitive dysfunction in Alzheimer's disease (AD) and have been a primary target in the development of drug treatments for AD. The present study utilized a mouse model of AD induced by intrahippocampal injection of AβO (10 μM) to investigate the effects of Gami-Chunghyuldan (GCD), a standardized multi-herbal medicinal formula, on the presentation of memory deficits and neurohistological pathogenesis. GCD (10 and 50mg/kg/day, 5 days, p.o.) improved AβO-induced memory impairment as well as reduced neuronal cell death, astrogliosis, and microgliosis in the hippocampus. In addition, GCD prevented AβO-triggered synaptic disruption and cholinergic fiber loss. These results suggest that GCD may be useful in the prevention and treatment of AD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / drug therapy
  • Amyloid beta-Peptides / pharmacology*
  • Animals
  • Drugs, Chinese Herbal / pharmacology*
  • Drugs, Chinese Herbal / therapeutic use
  • Hippocampus / drug effects*
  • Hippocampus / pathology
  • Male
  • Memory / drug effects*
  • Memory Disorders / chemically induced
  • Memory Disorders / drug therapy*
  • Memory Disorders / pathology
  • Mice
  • Nerve Degeneration / chemically induced
  • Nerve Degeneration / drug therapy*
  • Nerve Degeneration / pathology
  • Neurons / drug effects
  • Neurons / pathology
  • Peptide Fragments / pharmacology*
  • Synapses / drug effects
  • Synapses / pathology

Substances

  • Amyloid beta-Peptides
  • Chunghyuldan
  • Drugs, Chinese Herbal
  • Peptide Fragments