Abstract
Monoclonal antibodies recognizing human papillomavirus type 11 (HPV-11) were prepared from BALB/c mice immunized with intact HPV-11 virions obtained from morphologically transformed human foreskin xenografts grown subrenally in athymic mice. Four of five monoclonal antibodies that were reactive by enzyme-linked immunosorbent assay only to intact virions neutralized HPV-11 infectivity in the athymic mouse xenograft system.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal / immunology*
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Antigens, Viral / immunology
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Condylomata Acuminata / immunology
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Condylomata Acuminata / microbiology
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DNA Probes, HPV
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Humans
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In Vitro Techniques
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Mice
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Mice, Nude
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Neutralization Tests
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Nucleic Acid Hybridization
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Papillomaviridae / immunology*
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Skin Transplantation
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Viral Proteins / immunology
Substances
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Antibodies, Monoclonal
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Antigens, Viral
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DNA Probes, HPV
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Viral Proteins