Randomized comparison of Nd YAG laser, heater probe, and no endoscopic therapy for bleeding peptic ulcers

Gastroenterology. 1990 May;98(5 Pt 1):1239-44. doi: 10.1016/0016-5085(90)90339-3.

Abstract

Of 550 patients admitted with acute upper gastrointestinal hemorrhage, 143 with peptic ulcers containing stigmata of recent hemorrhage accessible to endoscopic therapy were included in a randomized comparison of neodymium yttrium aluminum garnet laser, heater probe, and no endoscopic therapy. The rebleeding rate in laser-treated patients (20%) was significantly less than in controls (42%; p less than 0.05), but in heater probe-treated patients (28%) it was not significantly different from either of the other two groups. The mortality rate in the laser group (2%) was not significantly different from either the heater probe (10%) or the control (9%) group. This trial has confirmed the efficacy of the Nd YAG laser but not that of the heater probe in the prevention of rebleeding from recently bleeding peptic ulcers.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Duodenal Ulcer / complications*
  • Duodenal Ulcer / mortality
  • Duodenal Ulcer / surgery
  • Duodenoscopy*
  • Electrocoagulation* / instrumentation
  • Electrocoagulation* / methods
  • Emergencies
  • Evaluation Studies as Topic
  • Gastroscopy*
  • Humans
  • Light Coagulation* / instrumentation
  • Light Coagulation* / methods
  • Peptic Ulcer Hemorrhage / mortality
  • Peptic Ulcer Hemorrhage / surgery*
  • Randomized Controlled Trials as Topic
  • Recurrence
  • Stomach Ulcer / complications*
  • Stomach Ulcer / mortality
  • Stomach Ulcer / surgery