ChimeraScan: a tool for identifying chimeric transcription in sequencing data

Matthew K Iyer; Arul M Chinnaiyan; Christopher A Maher

doi:10.1093/bioinformatics/btr467

ChimeraScan: a tool for identifying chimeric transcription in sequencing data

Bioinformatics. 2011 Oct 15;27(20):2903-4. doi: 10.1093/bioinformatics/btr467. Epub 2011 Aug 11.

Authors

Matthew K Iyer¹, Arul M Chinnaiyan, Christopher A Maher

Affiliation

¹ Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Abstract

Summary: Next generation sequencing (NGS) technologies have enabled de novo gene fusion discovery that could reveal candidates with therapeutic significance in cancer. Here we present an open-source software package, ChimeraScan, for the discovery of chimeric transcription between two independent transcripts in high-throughput transcriptome sequencing data.

Availability: http://chimerascan.googlecode.com

Contact: cmaher@dom.wustl.edu

Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Cell Line, Tumor
Gene Expression Profiling
Gene Fusion*
High-Throughput Nucleotide Sequencing*
Humans
Neoplasms / genetics*
Sequence Analysis, RNA*
Software*
Transcription, Genetic

Abstract

Publication types

MeSH terms

Grants and funding