Serum thymic factor as a radioprotective agent promoting survival after X-irradiation

H Kobayashi; H Abe; A Awaya; H Inano; M Shikita

doi:10.1007/BF01954239

Serum thymic factor as a radioprotective agent promoting survival after X-irradiation

Experientia. 1990 May 15;46(5):484-6. doi: 10.1007/BF01954239.

Authors

H Kobayashi¹, H Abe, A Awaya, H Inano, M Shikita

Affiliation

¹ Institute of Biological Science, Mitsui Pharmaceuticals, Inc., Mobara, Japan.

PMID: 2189748
DOI: 10.1007/BF01954239

Abstract

Serum thymic factor (FTS, zinc-free thymulin) protected mice from death after whole-body X-irradiation. It was significantly radioprotective even when administered after irradiation, but it was more effective when administered both before and after irradiation. The protective effect appears to be due to the enhancement of hematologic recovery in the animals.

MeSH terms

Animals
Cell Division / drug effects
Leukocyte Count / drug effects
Male
Mice
Mice, Inbred C3H
Organ Size / drug effects
Radiation Injuries, Experimental / blood
Radiation Injuries, Experimental / mortality
Radiation Injuries, Experimental / prevention & control*
Radiation-Protective Agents*
Spleen / cytology
Spleen / drug effects
Survival Rate
Thymic Factor, Circulating / administration & dosage
Thymic Factor, Circulating / pharmacology*
Thymus Hormones / pharmacology*
Whole-Body Irradiation*

Substances

Radiation-Protective Agents
Thymus Hormones
Thymic Factor, Circulating