Acellular dermal matrix (ADM) is a recently-developed, biologically-derived product with many useful applications in plastic surgery, in both cosmetic and reconstructive procedures. While the use of ADM initially outpaced quality literature, within the past 10 years the literature on ADM has rapidly expanded. Some of these data show promising results in treating historically-challenging problems within our field; thus, an effort to clarify and summarize existing work with ADM is indicated. While subsequent articles in this supplement focus on specific applications, this article provides a general overview of the biology of, applications for, and existing literature on ADM.