Abstract
Objectives:
To evaluate carbonyl groups (CG) serum levels in B-chronic lymphocytic leukemia (B-CLL) patients.
Design and methods:
CG serum levels were assessed in 48 B-CLL patients and in 30 control subjects.
Results:
CG were increased in B-CLL patients. We found a positive correlation between CG with CD38 expression and a negative correlation with ZAP 70 expression.
Conclusions:
B-CLL patients displayed an unbalance of the oxidative stress. CG serum levels could be considered as a prognostic factor in B-CLL.
Copyright © 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
MeSH terms
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ADP-ribosyl Cyclase 1
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Aged
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Aged, 80 and over
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Biomarkers, Tumor / blood*
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Blood Proteins / metabolism*
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Catalase / blood
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Female
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Humans
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Immunoglobulin Heavy Chains / genetics
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Immunoglobulin Variable Region / genetics
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Leukemia, Lymphocytic, Chronic, B-Cell / blood*
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Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis
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Leukemia, Lymphocytic, Chronic, B-Cell / physiopathology
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Male
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Malondialdehyde / blood
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Membrane Glycoproteins
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Middle Aged
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Neoplasm Staging
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Oxidative Stress
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Prognosis
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Protein Carbonylation*
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ZAP-70 Protein-Tyrosine Kinase / blood*
Substances
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Biomarkers, Tumor
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Blood Proteins
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Immunoglobulin Heavy Chains
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Immunoglobulin Variable Region
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Membrane Glycoproteins
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Malondialdehyde
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Catalase
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ZAP-70 Protein-Tyrosine Kinase
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CD38 protein, human
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ADP-ribosyl Cyclase 1