Carbonyl group serum levels are associated with CD38 expression in patients with B chronic lymphocytic leukemia

Abstract

Objectives: To evaluate carbonyl groups (CG) serum levels in B-chronic lymphocytic leukemia (B-CLL) patients.

Design and methods: CG serum levels were assessed in 48 B-CLL patients and in 30 control subjects.

Results: CG were increased in B-CLL patients. We found a positive correlation between CG with CD38 expression and a negative correlation with ZAP 70 expression.

Conclusions: B-CLL patients displayed an unbalance of the oxidative stress. CG serum levels could be considered as a prognostic factor in B-CLL.