Rofecoxib analogues possessing a nitric oxide donor sulfohydroxamic acid (SO2NHOH) cyclooxygenase-2 pharmacophore: synthesis, molecular modeling, and biological evaluation as anti-inflammatory agents

ChemMedChem. 2012 Jan 2;7(1):62-7. doi: 10.1002/cmdc.201100393. Epub 2011 Oct 11.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemical synthesis
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / pharmacology
  • Cyclooxygenase 2 / metabolism
  • Cyclooxygenase 2 Inhibitors / chemical synthesis
  • Cyclooxygenase 2 Inhibitors / chemistry*
  • Cyclooxygenase 2 Inhibitors / pharmacology
  • Drug Design*
  • Humans
  • Hydroxamic Acids / chemical synthesis
  • Hydroxamic Acids / chemistry*
  • Hydroxamic Acids / pharmacology
  • Lactones / chemical synthesis
  • Lactones / chemistry*
  • Lactones / pharmacology
  • Male
  • Models, Molecular
  • Nitric Oxide / metabolism
  • Nitric Oxide Donors / chemical synthesis
  • Nitric Oxide Donors / chemistry*
  • Nitric Oxide Donors / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Sulfones / chemical synthesis
  • Sulfones / chemistry*
  • Sulfones / pharmacology

Substances

  • Anti-Inflammatory Agents
  • Cyclooxygenase 2 Inhibitors
  • Hydroxamic Acids
  • Lactones
  • Nitric Oxide Donors
  • Sulfones
  • rofecoxib
  • Nitric Oxide
  • Cyclooxygenase 2