Increased endothelin concentration in CSF from patients with subarachnoid hemorrhage

H Suzuki; S Sato; Y Suzuki; K Takekoshi; N Ishihara; S Shimoda

doi:10.1111/j.1600-0404.1990.tb01018.x

Increased endothelin concentration in CSF from patients with subarachnoid hemorrhage

Acta Neurol Scand. 1990 Jun;81(6):553-4. doi: 10.1111/j.1600-0404.1990.tb01018.x.

Authors

H Suzuki¹, S Sato, Y Suzuki, K Takekoshi, N Ishihara, S Shimoda

Affiliation

¹ Department of Endocrinology, Dokkyo University School of Medicine, Mibu, Japan.

PMID: 2220315
DOI: 10.1111/j.1600-0404.1990.tb01018.x

Abstract

A considerable quantity of endothelin-like immunoreactivity was demonstrated as present in the CSF of patients with subarachnoid hemorrhage. The endothelin levels in the CSF raised from 0.4 +/- 0.2 (Mean +/- SD) pmol/L at Day 0-1 to 2.2 +/- 0.6 pmol/L at Day 6 and the levels decreased gradually. The result suggest that endothelin may contribute the generation of vasospasm often observed in subarachnoid hemorrhage.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Endothelins / cerebrospinal fluid*
Female
Humans
Ischemic Attack, Transient / cerebrospinal fluid*
Male
Middle Aged
Radioimmunoassay
Subarachnoid Hemorrhage / cerebrospinal fluid*

Substances

Endothelins