Power surge: supporting cells "fuel" cancer cell mitochondria

Ubaldo E Martinez-Outschoorn; Federica Sotgia; Michael P Lisanti

doi:10.1016/j.cmet.2011.12.011

Power surge: supporting cells "fuel" cancer cell mitochondria

Cell Metab. 2012 Jan 4;15(1):4-5. doi: 10.1016/j.cmet.2011.12.011.

Authors

Ubaldo E Martinez-Outschoorn¹, Federica Sotgia, Michael P Lisanti

Affiliation

¹ The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

PMID: 22225869
DOI: 10.1016/j.cmet.2011.12.011

Abstract

An emerging paradigm in tumor metabolism is that catabolism in host cells "fuels" the anabolic growth of cancer cells via energy transfer. A study in Nature Medicine (Nieman et al., 2011) supports this; they show that triglyceride catabolism in adipocytes drives ovarian cancer metastasis by providing fatty acids as mitochondrial fuels.

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