Abstract
Zanthoxylum chiloperone var. angustifolium root bark was studied with the aim of finding novel molecules able to overcome cancer stem cell chemoresistance. Purification of a methanol-soluble extract resulted in the isolation of a known pyranocoumarin, trans-avicennol (1). Compound 1 demonstrated antiproliferative activity on glioma-initiating cells, whereas it was inactive on human neural stem cells. trans-Avicennol (1) activated the MAPK/ERK pathway and was also evaluated for its ability to inhibit the enzyme indoleamine-2,3-dioxygenase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Coumarins / chemistry
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Coumarins / isolation & purification*
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Coumarins / pharmacology*
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Humans
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Indoleamine-Pyrrole 2,3,-Dioxygenase / antagonists & inhibitors
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Mice
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Mitogen-Activated Protein Kinase Kinases / drug effects
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Molecular Structure
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Neural Stem Cells / drug effects*
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Paraguay
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Plant Bark / chemistry
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Pyrones / chemistry
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Pyrones / isolation & purification*
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Pyrones / pharmacology*
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Stereoisomerism
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Zanthoxylum / chemistry*
Substances
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Antineoplastic Agents, Phytogenic
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Coumarins
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Indoleamine-Pyrrole 2,3,-Dioxygenase
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Pyrones
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trans-avicennol
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Mitogen-Activated Protein Kinase Kinases