Is mechanical stress an important pathogenic factor in hidradenitis suppurativa?

Exp Dermatol. 2012 Mar;21(3):176-7. doi: 10.1111/j.1600-0625.2012.01443.x.

Abstract

Hidradenitis suppurativa (HS) is a chronic of recurrent, inflammatory, follicular disease that usually presents after puberty with painful deep-seated, inflamed lesions in the inverse skin areas of the body. It has been hypothesized that mechanical pressure or friction is a risk factor for HS. We describe the case of a man with a lower leg amputation who presented HS-like lesions on his leg stump after wearing a leg prosthesis. Although pilonidal sinus-like disease could not be excluded, we diagnosed him with HS-like lesions, induced by prosthesis-related friction. We argue that this case supports the concept that mechanical friction and a warm humid microclimate by occlusion contribute to HS development.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amputation Stumps*
  • Artificial Limbs / adverse effects*
  • Cutaneous Fistula / diagnosis
  • Cutaneous Fistula / surgery
  • Hidradenitis Suppurativa / etiology*
  • Hot Temperature / adverse effects
  • Humans
  • Humidity / adverse effects
  • Leg Dermatoses / etiology*
  • Male
  • Microclimate
  • Prosthesis-Related Infections / complications*
  • Stress, Mechanical*