Enterobacteriaceae producing the KPC-2 carbapenemase from hospital sewage

Diagn Microbiol Infect Dis. 2012 Jun;73(2):204-6. doi: 10.1016/j.diagmicrobio.2012.02.007. Epub 2012 Mar 29.

Abstract

Fifteen isolates with reduced susceptibility to meropenem were obtained from hospital sewage. They contained bla(KPC-2) and belonged to multiple clones of Citrobacter freundii or Enterobacter cloacae. bla(KPC-2) was commonly carried by self-transmissible plasmids with different EcoRI-restricted patterns. Tn2 was identified upstream of bla(KPC-2), while ISKpn6 lay downstream. Hospital sewage could be an important reservoir of bla(KPC-2) and warrants more studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / biosynthesis*
  • Bacterial Proteins / genetics
  • Citrobacter freundii / drug effects
  • Citrobacter freundii / enzymology
  • Citrobacter freundii / genetics
  • Citrobacter freundii / isolation & purification*
  • Drug Resistance, Bacterial
  • Enterobacter cloacae / drug effects
  • Enterobacter cloacae / enzymology
  • Enterobacter cloacae / genetics
  • Enterobacter cloacae / isolation & purification*
  • Hospitals*
  • Meropenem
  • Sewage / microbiology*
  • Thienamycins / pharmacology
  • beta-Lactamases / biosynthesis*
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Sewage
  • Thienamycins
  • beta-lactamase KPC-2
  • beta-Lactamases
  • Meropenem