Abstract
Fifteen isolates with reduced susceptibility to meropenem were obtained from hospital sewage. They contained bla(KPC-2) and belonged to multiple clones of Citrobacter freundii or Enterobacter cloacae. bla(KPC-2) was commonly carried by self-transmissible plasmids with different EcoRI-restricted patterns. Tn2 was identified upstream of bla(KPC-2), while ISKpn6 lay downstream. Hospital sewage could be an important reservoir of bla(KPC-2) and warrants more studies.
Copyright © 2012 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / biosynthesis*
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Bacterial Proteins / genetics
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Citrobacter freundii / drug effects
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Citrobacter freundii / enzymology
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Citrobacter freundii / genetics
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Citrobacter freundii / isolation & purification*
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Drug Resistance, Bacterial
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Enterobacter cloacae / drug effects
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Enterobacter cloacae / enzymology
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Enterobacter cloacae / genetics
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Enterobacter cloacae / isolation & purification*
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Hospitals*
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Meropenem
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Sewage / microbiology*
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Thienamycins / pharmacology
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beta-Lactamases / biosynthesis*
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beta-Lactamases / genetics
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Sewage
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Thienamycins
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beta-lactamase KPC-2
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beta-Lactamases
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Meropenem