Abstract
Adenine had a concentration-dependent relaxation action on the phenylephrine-contracted aorta ring, with an EC(50) value of 0.40±0.12 mM. This effect was also observed in the endothelium-denuded aorta. Among the adenine analogues, N-methyladenine and benzimidazole still evoked an apparent relaxation effect, while 1-, 3- or 7-methyladenine and imidazole were no longer vasodilators. These findings demonstrate that the imino group from the uncharged imidazolium moiety in adenine played a key role in the relaxation of the contracted aorta.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenine / analogs & derivatives*
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Adenine / pharmacology
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Animals
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Aorta, Thoracic / drug effects*
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Aorta, Thoracic / physiology
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Benzimidazoles / pharmacology
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Imidazoles / pharmacology
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Muscle Contraction / drug effects*
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Muscle Contraction / physiology
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Muscle, Smooth, Vascular / drug effects*
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Muscle, Smooth, Vascular / physiology
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Phenylephrine / pharmacology
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Rats
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Rats, Sprague-Dawley
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Structure-Activity Relationship
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Tissue Culture Techniques
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Vasoconstrictor Agents / pharmacology
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Vasodilator Agents / pharmacology*
Substances
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Benzimidazoles
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Imidazoles
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Vasoconstrictor Agents
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Vasodilator Agents
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Phenylephrine
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imidazole
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7-methyladenine
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benzimidazole
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Adenine