Abstract
Feeding a high-cholesterol diet with a water-soluble peanut skin polyphenol fraction to rats reduced their plasma cholesterol level, with an increase in fecal cholesterol excretion. The hypocholesterolemic effect was greater with the lower-molecular-weight rather than higher-molecular-weight polyphenol fraction. This effect was possibly due to some oligomeric polyphenols which reduced the solubility of dietary cholesterol in intestinal bile acid-emulsified micelles.
MeSH terms
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Animals
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Anticholesteremic Agents / administration & dosage
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Anticholesteremic Agents / isolation & purification
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Anticholesteremic Agents / therapeutic use*
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Arachis / chemistry*
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Bile Acids and Salts / metabolism
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Cholesterol, Dietary / administration & dosage
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Cholesterol, Dietary / blood
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Diet, High-Fat*
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Feces / chemistry
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Fruit / chemistry*
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Intestinal Mucosa / metabolism
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Liver / metabolism
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Male
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Polyphenols / administration & dosage
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Polyphenols / isolation & purification
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Polyphenols / therapeutic use*
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Rats
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Solubility
Substances
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Anticholesteremic Agents
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Bile Acids and Salts
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Cholesterol, Dietary
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Plant Extracts
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Polyphenols