A turn-on fluorescent probe based on hydroxylamine oxidation for detecting ferric ion selectively in living cells

Chem Commun (Camb). 2012 May 28;48(43):5310-2. doi: 10.1039/c2cc31426f. Epub 2012 Apr 17.

Abstract

We have described a turn on fluorescent probe BOD-NHOH based on hydroxylamine oxidation for detecting intracellular ferric ions. The probe comprises a signal transducer of BODIPY dye and a Fe(3+)-response modulator of hydroxylamine. It is readily employed for assessing intracellular ferric ion levels, and confocal imaging is achieved successfully.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boron Compounds / chemistry
  • Cell Line, Tumor
  • Ferric Compounds / analysis*
  • Fluorescent Dyes / chemistry*
  • Humans
  • Hydrogen-Ion Concentration
  • Hydroxylamine / chemistry*
  • Ions / chemistry
  • Microscopy, Confocal*
  • Oxidation-Reduction

Substances

  • 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
  • Boron Compounds
  • Ferric Compounds
  • Fluorescent Dyes
  • Ions
  • Hydroxylamine