Abstract
We herein report the anti-Alzheimer activity of some synthesized heterocyclic pyrimidine and thiopyrimidine derivatives fused with steroidal structure. Twenty-one of these compounds were synthesized and conveniently screened for their anti-Alzheimer activities using of Flurbiprofen as the reference drug. Some of these compounds were demonstrated to exhibit remarkable activity and their β-amyloid (Aβ) lowering results as IC(50) values reported.
Copyright © 2012 Elsevier B.V. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alzheimer Disease / drug therapy*
-
Alzheimer Disease / metabolism
-
Amyloid beta-Peptides / metabolism
-
Animals
-
Anti-Inflammatory Agents / chemistry
-
Anti-Inflammatory Agents / pharmacology
-
Cell Line
-
Cyclooxygenase Inhibitors / chemistry
-
Cyclooxygenase Inhibitors / pharmacology
-
Female
-
Heterocyclic Compounds / chemistry
-
Heterocyclic Compounds / pharmacology
-
Humans
-
Inhibitory Concentration 50
-
Male
-
Mice
-
Mice, Transgenic
-
Pyrimidines / chemical synthesis
-
Pyrimidines / chemistry*
-
Pyrimidines / pharmacology*
-
Steroids / chemical synthesis
-
Steroids / chemistry*
-
Steroids / pharmacology*
-
Structure-Activity Relationship
Substances
-
Amyloid beta-Peptides
-
Anti-Inflammatory Agents
-
Cyclooxygenase Inhibitors
-
Heterocyclic Compounds
-
Pyrimidines
-
Steroids