Nanoporous peptide particles for encapsulating and releasing neurotrophic factors in an animal model of neurodegeneration

Adv Mater. 2012 Jul 3;24(25):3362-6. doi: 10.1002/adma.201200634. Epub 2012 May 21.

Abstract

Neurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons (as indicated by the arrows) in the cochlea of guinea pigs with sensorineural hearing loss.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Brain-Derived Neurotrophic Factor / administration & dosage*
  • Brain-Derived Neurotrophic Factor / chemistry
  • Brain-Derived Neurotrophic Factor / pharmacology
  • Cell Line, Tumor
  • Cochlea / metabolism
  • Disease Models, Animal
  • Drug Carriers / chemistry*
  • Guinea Pigs
  • Hearing Loss, Sensorineural / chemically induced
  • Hearing Loss, Sensorineural / drug therapy*
  • Humans
  • Nanoparticles / chemistry*
  • Peptides / chemistry*
  • Porosity

Substances

  • Brain-Derived Neurotrophic Factor
  • Drug Carriers
  • Peptides
  • polyglutamine