Abstract
We investigated the prevalence of plasmid-mediated quinolone resistance (PMQR) determinants and examined the association of these determinants with extended-spectrum β-lactamases (ESBLs) and/or plasmid-mediated AmpC β-lactamases (pAmpCs) in Serratia marcescens isolates in China. In this study, the presence of PMQR determinants was significantly related to the coproduction of ESBLs and/or pAmpCs (CTX-M-14, SHV-5, DHA-1, and ACT-1), among which CTX-M-14 was the most common gene type.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Bacterial Agents / pharmacology*
-
Bacterial Proteins / biosynthesis
-
Bacterial Proteins / genetics*
-
China
-
Ciprofloxacin / pharmacology
-
Drug Resistance, Multiple, Bacterial / genetics
-
Humans
-
Microbial Sensitivity Tests
-
Ofloxacin / pharmacology
-
Plasmids* / genetics
-
Quinolones / pharmacology*
-
Serratia Infections / drug therapy
-
Serratia Infections / microbiology
-
Serratia marcescens / drug effects*
-
Serratia marcescens / genetics*
-
Serratia marcescens / isolation & purification
-
beta-Lactam Resistance / genetics
-
beta-Lactamases / biosynthesis
-
beta-Lactamases / genetics*
Substances
-
Anti-Bacterial Agents
-
Bacterial Proteins
-
Quinolones
-
Ciprofloxacin
-
Ofloxacin
-
beta-lactamase CTX-M-14
-
AmpC beta-lactamases
-
beta-Lactamases