BODIPY based colorimetric fluorescent probe for selective thiophenol detection: theoretical and experimental studies

Analyst. 2012 Sep 7;137(17):3921-4. doi: 10.1039/c2an35524h. Epub 2012 Jul 3.

Abstract

A BODIPY-based selective thiophenol probe capable of discriminating aliphatic thiols is reported. The fluorescence off-on effect upon reaction with thiol is elucidated with theoretical calculations. The sensing of thiophenol is associated with a color change from red to yellow and 63-fold enhancement in green fluorescence. Application of the probe for selective thiophenol detection is demonstrated by live cell imaging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boron Compounds / chemistry*
  • Colorimetry*
  • Fluorescent Dyes / chemistry*
  • HeLa Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Models, Theoretical
  • Phenols / analysis*
  • Quantum Theory
  • Sulfhydryl Compounds / analysis*
  • Sulfhydryl Compounds / chemistry

Substances

  • 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
  • Boron Compounds
  • Fluorescent Dyes
  • Phenols
  • Sulfhydryl Compounds
  • thiophenol