Direct fluorination of phenolsulfonphthalein: a method for synthesis of positron-emitting indicators for in vivo pH measurement

Cell Biochem Biophys. 2013 May;66(1):1-5. doi: 10.1007/s12013-012-9390-x.

Abstract

We report a reaction of direct electrophilic fluorination of phenolsulfonphthalein at mild conditions. This reaction affords the synthesis of novel positron-emitting (18)F-labeled pH indicators. These compounds are useful for non-invasive in vivo pH measurement in biological objects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetic Acid / chemistry
  • Electrons*
  • Fluorine / chemistry
  • Fluorine Radioisotopes / chemistry
  • Halogenation*
  • Hydrogen-Ion Concentration
  • Indicators and Reagents / chemical synthesis
  • Indicators and Reagents / chemistry
  • Molecular Structure
  • Phenolsulfonphthalein / chemistry*

Substances

  • Fluorine Radioisotopes
  • Indicators and Reagents
  • Fluorine
  • Phenolsulfonphthalein
  • Acetic Acid