Abstract
We report a reaction of direct electrophilic fluorination of phenolsulfonphthalein at mild conditions. This reaction affords the synthesis of novel positron-emitting (18)F-labeled pH indicators. These compounds are useful for non-invasive in vivo pH measurement in biological objects.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acetic Acid / chemistry
-
Electrons*
-
Fluorine / chemistry
-
Fluorine Radioisotopes / chemistry
-
Halogenation*
-
Hydrogen-Ion Concentration
-
Indicators and Reagents / chemical synthesis
-
Indicators and Reagents / chemistry
-
Molecular Structure
-
Phenolsulfonphthalein / chemistry*
Substances
-
Fluorine Radioisotopes
-
Indicators and Reagents
-
Fluorine
-
Phenolsulfonphthalein
-
Acetic Acid