This study explored group differences among a treatment-seeking sample of hypersexual women (n = 31) and hypersexual men (n = 47) across facets of personality using the NEO-Personality Inventory-Revised and the Hyper sexual Behavior Inventory. A number of striking parallels emerged between the two groups, including similar levels of impulsivity, emotional dysregulation, and difficulties coping with stress. Hypersexual women, compared to men, exhibited higher levels of distrust toward others, lower levels of self-confidence and ambition, and a greater preference for excitement and stimulation. These findings suggest that several common facets of personality precipitate or perpetuate hypersexual behavior in men and women, with some variations across genders. The implications of these findings for treatment interventions are discussed.