Abstract
A bicyclam-based biodegradable polycation with CXCR4 antagonistic activity was developed with potential for combined drug/gene cancer therapies. The dual-function polycation prevents cancer cell invasion by inhibiting CXCL12 stimulated CXCR4 activation, while at the same time efficiently and safely delivers plasmid DNA into cancer cells.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzylamines
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Cell Line, Tumor
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Cell Movement / drug effects
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Cell Survival / drug effects
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Chemokine CXCL12 / agonists
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Chemokine CXCL12 / metabolism
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Cyclams
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Gene Transfer Techniques
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Hep G2 Cells
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Heterocyclic Compounds / chemical synthesis
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Heterocyclic Compounds / chemistry*
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Heterocyclic Compounds / toxicity
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Humans
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RNA Interference
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RNA, Small Interfering / chemistry
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RNA, Small Interfering / metabolism
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Receptors, CXCR4 / antagonists & inhibitors*
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Receptors, CXCR4 / genetics
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Receptors, CXCR4 / metabolism
Substances
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Benzylamines
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Chemokine CXCL12
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Cyclams
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Heterocyclic Compounds
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RNA, Small Interfering
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Receptors, CXCR4
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plerixafor