Abstract
AL18, an inhibitor of human cytomegalovirus DNA polymerase, was serendipitously found to also block the interaction between the PB1 and PA polymerase subunits of influenza A virus. Furthermore, AL18 effectively inhibited influenza A virus polymerase activity and the overall replication of influenza A and B viruses. A molecular model to explain the binding of AL18 to both cytomegalovirus and influenza targets is proposed. Thus, AL18 represents an interesting lead for the development of new antivirals.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anthraquinones / chemistry
-
Anthraquinones / pharmacology*
-
Antiviral Agents / chemistry
-
Antiviral Agents / pharmacology*
-
Cytomegalovirus / drug effects
-
Cytomegalovirus / enzymology
-
DNA-Directed DNA Polymerase / chemistry
-
DNA-Directed DNA Polymerase / metabolism
-
Enzyme Inhibitors / chemistry
-
Enzyme Inhibitors / pharmacology*
-
HEK293 Cells
-
Humans
-
Influenza A virus / drug effects*
-
Influenza A virus / enzymology
-
Influenza B virus / drug effects*
-
Influenza B virus / enzymology
-
Influenza, Human / drug therapy
-
Influenza, Human / virology
-
Molecular Docking Simulation
-
Nucleic Acid Synthesis Inhibitors
-
RNA-Dependent RNA Polymerase / antagonists & inhibitors*
-
RNA-Dependent RNA Polymerase / chemistry
-
RNA-Dependent RNA Polymerase / metabolism
-
Transfection
-
Viral Proteins / antagonists & inhibitors*
-
Viral Proteins / chemistry
-
Viral Proteins / metabolism
Substances
-
AL18 compound
-
Anthraquinones
-
Antiviral Agents
-
Enzyme Inhibitors
-
Nucleic Acid Synthesis Inhibitors
-
PA protein, influenza viruses
-
Viral Proteins
-
influenza virus polymerase basic protein 1
-
RNA-Dependent RNA Polymerase
-
DNA-Directed DNA Polymerase